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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
30.8
Human Site:
Y4
Identified Species:
48.4
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
Y4
_
_
_
_
M
K
D
Y
D
E
L
L
K
Y
Y
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
Y4
_
_
_
_
M
K
D
Y
D
E
L
L
K
Y
Y
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
Y4
_
_
_
_
M
K
D
Y
E
E
L
L
K
Y
Y
Dog
Lupus familis
XP_538730
651
74149
Y4
_
_
_
_
M
K
D
Y
D
E
L
L
K
Y
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
Y4
_
_
_
_
M
K
D
Y
D
E
L
L
K
Y
Y
Rat
Rattus norvegicus
P54645
559
63955
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
Y6
_
_
M
A
A
G
D
Y
D
D
L
L
K
Y
Y
Chicken
Gallus gallus
NP_001026680
657
74208
Y6
_
_
M
S
V
S
D
Y
E
E
I
L
K
Y
Y
Frog
Xenopus laevis
NP_001081569
651
74289
Y6
_
_
M
A
V
D
D
Y
E
E
L
L
K
Y
Y
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
P52
A
A
A
A
C
R
P
P
L
A
R
V
G
Y
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
Y4
_
_
_
_
M
S
K
Y
E
V
L
Q
G
F
Y
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
W280
Q
T
A
M
D
S
D
W
N
E
I
K
H
R
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
N4
_
_
_
_
M
S
S
N
N
N
T
N
T
A
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
90.9
100
N.A.
100
0
N.A.
61.5
53.8
61.5
13.3
N.A.
N.A.
0
36.3
20
P-Site Similarity:
100
100
100
100
N.A.
100
0
N.A.
69.2
76.9
76.9
26.6
N.A.
N.A.
0
54.5
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
9
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
18.1
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
14
20
7
0
0
0
0
7
0
0
0
7
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
7
60
0
34
7
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
27
54
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
0
0
0
0
0
7
0
0
0
0
0
0
14
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
14
0
0
0
0
% I
% Lys:
0
0
0
0
0
34
7
0
0
0
0
7
54
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
7
0
54
54
0
0
0
% L
% Met:
0
0
20
7
47
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
7
14
7
0
7
0
0
0
% N
% Pro:
0
0
0
0
0
0
7
7
0
0
0
0
0
0
7
% P
% Gln:
7
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% Q
% Arg:
0
0
0
0
0
7
0
0
0
0
7
0
0
7
0
% R
% Ser:
0
0
0
7
0
27
7
0
0
0
0
0
0
0
0
% S
% Thr:
0
7
0
0
0
0
0
0
0
0
7
0
7
0
0
% T
% Val:
0
0
0
0
14
0
0
0
0
7
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
60
0
0
0
0
0
60
74
% Y
% Spaces:
67
67
47
47
0
0
0
0
0
0
0
0
0
0
0
% _